Chapter 5

B

otulinum Toxine

Video Description:

Botulinum toxin is the most toxic natural poison in the world. 1 gram can kill 100.000 humans - or 9000 horses
It is used for face lifting in a very small dose.

1. Overview synaptic cleft and botulinum toxin (black rings)

2. Process of entering the axon.

3. Botox (Botulinum toxin A) binds to the synaptic vesicles...

4. ...so that no transmitters can enter the synaptic cleft. Botulinum toxin hinders the synaptic vesicles from exocytosis. It binds to the Axon membrane, so they cannot discharge the neurotransmitter Acetylcholine

5. What happens to the synaptic cleft if botox takes effect on a synapse, is that no action potential is released in the next nerve cell. If so, no signal transmission to a muscle happens. The muscle relaxes. The crinkels disappear
If the lethal dose, 0,01 milligrams, gets into the body, the lungs stop breathing. Death by respiratory paralysis. The antidote to botox is the toxin of the Black Widow...